
Precision therapeutics for major unmet medical needs
About Us
Changing the way we treat disease
We have a decade of data informing our strategy including patient responder analyses, rigorous dose modeling and flawless clinical execution. As a result, our therapeutic candidates have maximum potential for patient impact. Find out more about the SPRING trial for P. gingivalis positive Alzheimer's disease.

News & Events
Lighthouse Pharmaceuticals to Present Phase 2 SPRING Trial of LHP588, a Next-Generation Gingipain Inhibitor for the Treatment of P. gingivalis-Positive Alzheimer’s Disease, at CTAD 2025
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Lighthouse Pharmaceuticals Relocates Headquarters to the Buck Institute for Research on Aging
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Phibro Animal Health Corporation Announces Licensing Agreement with Lighthouse Pharmaceuticals, Inc. for Innovative Periodontal Health Asset for Dogs
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Lighthouse Pharmaceuticals Receives $49.2 Million Grant from NIA to Advance Phase 2 Study of LHP588 for P. gingivalis-Positive Alzheimer’s Disease
Groundbreaking Clinical Trial to Enroll 300 Patients in Double-Blind, Placebo-Controlled Study of Lysine-Gingipain Inhibitor
Lighthouse Pharmaceuticals Initiates Phase 2 SPRING Trial of LHP588 in P. gingivalis-Positive Alzheimer’s Disease
48-Week Study to Evaluate the Safety and Efficacy of Oral LHP588 Dosed Once Daily






